How do you proceed with treatment of a patient with stage IIIB NSCLC who progresses DURING treatment with concurrent weekly carboplatin/paclitaxel and radiation?

I have been looking at this question for a little over a week, and struggling to know how to answer this. The relevant trials for a patient with PDL1 somewhere between 0 and 49% (KEYNOTE-189, KEYNOTE-407, KEYNOTE-042, CheckMate 227, and 9LA) would have excluded patients who received either adjuvant ...

This is a low platinum dose. I would most likely switch to chemo and immunotherapy. I would be concerned about pneumonitis with a combined immunotherapy approach initially with the near use of radiation. If after 2 cycles the response is unsatisfactory, one could try then an ipi, nivo approach.