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When will you choose Tarlatamab over an alternative systemic therapy (e.g. lurbinectedin, topotecan) for relapsed ES SCLC?

What is your preferred sequencing of available therapies for a patient who remains fit for several lines of treatment?
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In which patient types would you prioritize Tarlatamab first over alternative systemic therapy options for relapsed ES SCLC?

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2 Answers
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Medical Oncology · University of Colorado Anschutz Medical Center
Answered on · Updated on

I generally offer tarlatamab as a second line option in small cell lung cancer patients who are fit (ECOG 0-1), can logistically accommodate the hospitalization and infusion schedule, have low-risk factors for ICANS, and have treated brain metastases. I would consider a platinum etoposide rechalleng...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Michigan
Answered on

I have used lurbinectedin as my second line. As tarlatamab was studied in patients who had 2 or more prior lines of therapy in the DeLLphi-301 study, I have started using it as my preferred third line treatment.

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