How do you sequence chemoradiation and chemotherapy for patients with locally advanced rectal cancer undergoing TNT based upon data from CAO/ARO/AIO-12?
In practice, does starting with chemoradiation followed by chemotherapy result in a significant delay in initiating chemotherapy or a patient's ability to tolerate 3-4 months of chemotherapy?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
Answered on
At our center, we give Total Neoadjuvant Therapy (TNT) for rectal cancer, with chemotherapy delivered up-front, followed by radiation (short-course vs long course chemo-XRT).
We do not use the CAO/ARO/AIO-12 study as a blueprint for our approach. CAO/ARO/AIO-12 was a phase II study of TNT evaluating ...
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