How do you sequence chemoradiation and chemotherapy for patients with locally advanced rectal cancer undergoing TNT based upon data from CAO/ARO/AIO-12?

At our center, we give Total Neoadjuvant Therapy (TNT) for rectal cancer, with chemotherapy delivered up-front, followed by radiation (short-course vs long course chemo-XRT).

We do not use the CAO/ARO/AIO-12 study as a blueprint for our approach. CAO/ARO/AIO-12 was a phase II study of TNT evaluating ...