How do you sequence chemotherapy with radiotherapy for advanced endometrial cancer?

Unfortunately, we don’t even know for sure if we need RT for stage III disease.

GOG 258 showed early concurrent chemo RT is no better than chemotherapy alone (delaying chemo increased distant mets, which probably negated locoregional control benefit of RT). For this reason, chemotherapy has become st...

This is an excellent question that speaks to the numerous recent developments, and ongoing controversies, regarding the ideal adjuvant approach to stage III endometrial cancer.

One big takeaway is that stage III EC is an extremely heterogeneous population, consisting of patients with wildly different...

Typically treat with six cycles of adjuvant chemotherapy followed by radiation. Can consider the sandwich technique supported by data from Duke. I think GOG 258 is thought-provoking and can support chemotherapy alone. I would keep in mind that this trial had a high percentage of lymph node-positive ...

I also tend to deliver concurrent chemo/RT followed by chemotherapy.