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How do you treat ADHD with short periods of benefit from stimulant medications?
I have some pediatric patients who only see 4-5 hours of benefit with XR formulations. Is there a reason for this or another diagnosis I should be considering when I see this?
Background
1. children have higher metabolism and rate of elimination of most drugs
2. children have more variable pharmacokinetics
3. alleged "hours of benefit" may not be reliable
Options
1. increase dose
2. dose twice a day (morning, noon)
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