How do you treat anaplastic multiple myeloma?

What features are used to distinguish anaplastic multiple myeloma (AMM), and what other conditions should be considered in a differential diagnosis (eg. plasmablastic lymphoma)?

Does the presence of circulating plasma cells (ie. plasma cell leukemia) influence your treatment choice?

Answer from: Medical Oncologist at Academic Institution

I would defer to a hematopathologist for a more detailed discussion of the morphological features, but in general anaplastic myeloma is characterized by cells that are so pleomorphic and poorly differentiated as to bear little resemblance to plasma cells. Because of this, the diagnosis can sometimes...

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