How do you treat anaplastic multiple myeloma?

I would defer to a hematopathologist for a more detailed discussion of the morphological features, but in general anaplastic myeloma is characterized by cells that are so pleomorphic and poorly differentiated as to bear little resemblance to plasma cells. Because of this, the diagnosis can sometimes be very challenging, particularly if there is not otherwise a suspicion for a plasma cell disorder. My colleagues and I published a brief report several years ago describing two cases of anaplastic myeloma (Ammannagari et al., Clin Lymph Myel Leuk 2016). In the first case, the preliminary diagnosis was possible angiosarcoma, before additional work-up was performed.

Anaplastic myeloma is extremely aggressive and is commonly associated with extensi...