How do you treat restless leg syndrome in patients with end-stage renal disease?

Based on the 2025 guidelines for RLS in patients with ESRD, I would recommend first checking iron studies and using IV iron sucrose if ferritin and transferrin saturation meet the criteria since the use of iron in this population has moderate certainty of evidence. If an iron infusion is not helpful, then can consider other treatments such as vitamin C, then levodopa, followed by gabapentin (as these treatments have low and very low certainty of evidence, respectively). For gabapentin, dose adju...