How do your PMRT recommendations change with ITCs after neoadjuvant chemotherapy if they had SLNB only versus ALND in light of B51?

Data such as from Dana-Farber/Brigham and Women’s Cancer Center and the National Cancer Database (Wong et al., PMID 31228134), as well as the OPBC-05/ICARO study (Montagna et al., PMID 39509672), indicate that patients with isolated tumor cells in axillary nodes after neoadjuvant chemotherapy (ypN0i...

Montagna et al., PMID 39509672

This is the largest data set with ITC post-chemo highlighting the risk of additional disease and showing no impact of ALND on outcome.

75% got RNI and even though a small 4/5 axillary recurrence was seen in the group that didn’t have RNI, I favor post-chemo ITC to be tre...