How does a diffusely positive PSMA in the prostate affect treatment planning in a patient with MRI and biopsy showing only one area of disease?

Topics: Radiation Oncology • Genitourinary Cancers • Prostate Cancer

Would you consider repeating a biopsy?

Answer from: Radiation Oncologist at Academic Institution

There are three parts to my answer: First, mild to moderate PSMA uptake can be seen in benign conditions, including BPH and prostatitis (e.g., reviewed by Satapathy et al., PMID 32755196). Second, I don't see how the discrepancy between PSMA PET and MRI/biopsy would affect radiation treatment plan...

Comments

Radiation Oncologist at Lafayette Radiation Center
FLAME per mpMRI, PET adds nothing.

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