How does the lack of mandated PET or brain MRI in the ADAURA trial impact your interpretation of the results?

The lack of mandated PET or brain MRI do affect study interpretation but I don’t think they change the bottom line. Lack of mandated PET (need for baseline PET scan has significant global variation) may understage some patients who might have occult local-regional or metastatic disease. This would i...

The lack of PET and MRI does not affect things at all. This was a real world study and some patients had PET and some patients did not. All patients had a scan after resection and some sort of brain imaging prior to starting the osimertinib. I feel that the data will ultimately show that this was eq...

The trial requested a brain MRI, but a CT brain was acceptable. If a scan had not been done before surgery, it had to be done before randomization. While a brain MRI is generally standard of care, there certainly are cases in which one cannot be obtained.

A PET scan was not required by trial. The pr...

Per the supplementary information accompanying the NEJM paper on ADAURA, "Baseline CT scans (chest and abdomen) were obtained to confirm lack of metastatic disease prior to randomization. MRI or CT scan of the brain was required prior to surgery or randomization. No more that 26 or 10 weeks may have...