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Topics:
General Internal Medicine • Infectious Disease • Dermatology • Derm-Infectious Disease • General Infectious Disease • General Primary Care • General Hospital Medicine
How does trimethoprim-sulfamethoxazole's efficacy against S. pyogenes influence your empirical treatment of skin infections in regions with high resistance rates?
Answer from: at Community Practice
I am a little confused by the question. Why would you use TMP/SMX monotherapy for SSTI? During the emergence of CA-MRSA, cephalexin with or without TMP/SMX had the same efficacy rates (Pallin). I agree with Dr. @Kaspar; linezolid is a great choice if MRSA is a concern. Cephalexin or cefadroxil are f...
Answer from: at Community Practice
Why I Still Don’t Understand Using TMP/SMX for SSTIs.
TMP/SMX has poor clinical activity against Gram-positive cocci to begin with. But the bigger issue is how it’s almost always dosed in practice. For SSTIs, Doctors prescribe Bactrim DS, 1 PO BID— the appropriate dose for cystiti...
Agree completely with Dr. @Smith's answer which re...
I’m not convinced because the PD of T/S is s...
For empiric treatment of purulent SSTI, if I use t...
With Linezolid being generic and cheap, and having...
Linezolid has become my antibiotic of choice for t...