How do you approach the discussion regarding loss of muscle mass with GLP-1 agonists in your non-geriatric population where the negative repercussions may not be as obvious?
"In a systematic review of 36 studies evaluating the effect of GLP-1-based medications on body composition, almost 35 percent of weight loss from these agents was attributable to reductions in muscle-based indices."
As published in: Batsis et al., PMID 41996180
2 Answers
Mednet MemberInvited Expert
Primary Care · VCU Medical Center
Answered on
We start by having the discussion PRIOR to starting the medication. We educate that this is not a GLP-1 phenomenon but a result of weight loss. We reinforce this at every dose change and at every follow-up, emphasizing protein and strength training. We use a body composition analysis scale to help p...
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Mednet MemberInvited Expert
Primary Care · Albert Einstein College of Medicine
Answered on
I mention this along with the other negative risks of GLP-1s. I consider this part of informed consent. So topics usually discussed are
- Main side effects such as nausea/vomiting/GI upset, etc.
- That these medications are likely to be considered chronic medications, as recent analysis shows 60% of we...
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