How long do you wait to repeat a 24 hour urine stone risk study after stopping topiramate in patient with recurrent calcium based kidney stones attributed to the medication?

Assuming normal or near normal GFR, topiramate should be effectively eliminated after approximately 5 days, and urine pH should have returned to its pretreatment level. If more data is desired, a 24-hour urine supersaturation could be collected then.

Topiramate predisposes to kidney stones by inhibiting carbonic anhydrase and raising urine pH, making the urinary milieu more favorable to the formation of calcium phosphate (brushite, hydroxyapatite) stones. It does not predispose users to the for...