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How often do you utilize soluble transferrin receptor or hepcidin testing in the diagnosis of ambiguous iron deficiency, such as with concomitant anemia of chronic disease?

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In cases of combined anemia, how have you parsed out concomitant iron deficiency in the setting of chronic inflammation?

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Hematology · Georgetown University School of Medicine
Answered on

Almost never. While the soluble transferrin receptor and serum hepcidin levels may provide useful information, their lack of ready availability and costs makes them inconvenient and inefficient as a standard. There is no evidence extant that either offers an advantage to the TSAT. All of this is a m...

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