How soon after an acute upper GI bleed do you restart therapeutic anticoagulation in a patient with atrial fibrillation and a high thromboembolic risk (CHA₂DS₂-VASc ≥4)?

In real-world inpatient practice:

• ~72 hours after endoscopic control for high-stroke-risk AF with stable hemoglobin and no rebleeding,
• Extending hold to 5–7 days if the lesion is high risk or the bleed was severe.