Unfortunately, there is no data at the moment to inform decisions about the optimal duration of sarilumab treatment for PMR patients and how to discontinue this medication. The clinical trial that demonstrated efficacy was limited to 12 months and the drug was stopped altogether after that period. N...

Initially, when using a drug for a new indication, like sarilumab in PMR, I tend to follow the protocol from the pivotal study. My thought would be for most patients, I will use sarilumab 200mg every other week for one year if the patient achieves clinical remission. At the one-year mark, if the pat...

For more than sixty years, the conversation on polymyalgia rheumatica (PMR) has resembled a phonograph needle stuck in a groove on a scratched 33 & 1/3 long playing record. In my opinion, the recent study by Spiera et al., PMID 37792612 in the NEJM, reporting on the use of sarilumab in PMR, has ...