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In a patient with high-risk cutaneous squamous cell carcinoma of the face with extracapsular extension after ipsilateral neck dissection and rapid contralateral cervical nodal recurrence, what is the optimal management? Is upfront systemic immunotherapy with cemiplimab appropriate, with response-adapted consolidation using radiotherapy versus concurrent chemoradiotherapy?
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Mednet Member
Medical Oncology · The Ohio State University Comprehensive Cancer Center
In our series of unresectable cutaneous cell carcinoma (about 125 cases), we have an almost 50% complete clinical remission with cemiplimab. This is now the treatment of choice for such patients. For those who do not respond and cannot be resected with salvage surgery, the best option is probably ip...