How would you approach a completely resected DLBCL of the appendix if PET scan and bone marrow biopsy suggest no other disease?

Resected limited stage DLBCL has relatively high risk of recurrence. A recent prospective phase II trial was reported (Yoon et al. Oncotarget 2017) where patients received 3 cycles of RCHOP post resection and had an excellent 2 year PFS of 95%. Another study (Sehn et al. Annals of Oncology 2008 abstract) didn't report resection status but treated patients with 4 cycles of RCHOP and had excellent 2 year PFS >90%. The caveat is that follow up duration in both studies is limited. Patients with limited stage DLBCL are at increased risk of late recurrence in comparison to advanced stage disease (Stephens et al. JCO 2016) so long term follow up of these studies is important. Based on above, 4 cycles of RCHOP after resection of limited stage DLBCL...