How would you approach a patient with a primary splenic DLBCL who has residual PET avid disease after 6 cycles of R-CHOP?

The treatment of DLBCL arising in the spleen would be very similar to the treatment of DLBCL at most other sites. After a full course of chemoimmunotherapy, if the patient has not achieved a complete response by PET-CT (Deauville 1-3), then the treating physicians need to make a judgment. The primar...

Prof. @Dr. First Last outlined treatment choices in a very elegant manner. Thank you for that!

I would like to add that splenectomy could be considered instead of RT if the DLBCL was limited to the spleen at diagnosis.