Topics:
Gastrointestinal Cancers • Medical Oncology • MD Anderson • NCI-CCC Tumor Board Question • NCI-CCC GI Tumor Board Question • Hepatocellular Carcinoma
How would you approach a patient with newly diagnosed hepatocellular carcinoma with very high AFP (>100,000) but no clear radiographic evidence of metastatic disease?
Previously untreated
Answer from: Medical Oncologist at Academic Institution
This is a challenging situation. Oftentimes, these patients have significant vascular involvement of their tumor. AFP has been shown to correlate with survival and those with markedly elevated (>100,000) have a very poor prognosis (REACH, REACH2, Zhu et al., PMID 33531690). If a patien...
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Answer from: Medical Oncologist at Community Practice
Elevated AFP levels are indicative of high tumor aggressivity, and microvascular invasion (MVI). (Fan et al., PMID 23321029) Post-treatment AFP response may serve as a non-invasive tool to monitor treatment efficacy and can predict the survival of HCC patients who were treated with liver transplant,...