How would you approach a post-menopausal female with both a previously HR+ HER2- breast cancer and HR- HER2+ breast cancer with new brain metastasis?  

How would you figure out how to treat someone with a prior localized HR+,HER2- breast cancer treated with adjuvant AC-T (5years ago) and a recent ipsilateral axillary recurrence (HR-,HER2+) s/p neoadjuvant TCHP followed by HP x 1 year?



Answer from: Medical Oncologist at Academic Institution