How would you approach a post-menopausal women with recurrent ER/PR+, HER2- breast cancer only in the axillary lymph nodes?

This sounds so characteristic of a low-grade ER+ tumor in an elderly lady. I would only resect and confirm at resection the above-suspected pathology. Clearly given her age indolent behavior, local recurrence and low volume I would not torture this elderly lady with nothing more than an AI. The prob...

Patients who relapse more than 10 years after diagnosis have a particularly favorable course.

She has an endocrine-sensitive disease just by the criteria of long disease-free survival. For example, in S0226 in a subset of patients who relapsed more than 10 years after initial diagnosis, we saw a med...

If not done already, I would make sure to obtain staging scans to ensure recurrence is limited to the ALN. Would refer to surgery for resection of the nodes and full ALND if not done before, and to radiation oncology for consideration of RT (assuming she has not received it before). Given she has a ...

ALND. RT. Anastrozole

Initially PET/CT to evaluate metastases.

Then chemotherapy (CALOR trial), followed by local treatment.