How would you approach adjuvant chemotherapy and radiation options in a patient with locally advanced TNBC and Diamond-Blackfan Anemia s/p lumpectomy?
Given that DBA is associated with increased incidence of MDS, AML and other solid tumors, would this modify your treatment recommendations?
Answer from: Medical Oncologist at Academic Institution
This is one of the many situations for which there is no good published data. In this circumstance, decisions need to be made based on weighing the risks and benefits and considering the patient's values and philosophies.
This patient has about a 30% chance of dying of metastatic breast cancer (can...
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