How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?

Topics: Pediatric Oncology • Medical Oncology • Hematology • Pediatric Hematology • Benign Hematology • Infectious Disease • Neutropenia

Is there a role for empiric antibiotics if there is history of opportunistic infection?

Answer from: at Academic Institution

My preference would be to use G-CSF at the lowest effective dose, i.e., the dose that maintains the ANC >1000. The risk of inducing leukemia is low in individuals with idiopathic, chronic neutropenia, but it is positively correlated with the G-CSF dose. There are also other side effects like bone...

Comments

at Kaiser Permanente, Los Angeles Med Center
Thank you so much, Dr. @Enrico Novelli!

at University of Pittsburgh
Absolutely, Dr. @Yang Jiang. Please let me know ho...

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