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Infectious Disease   

Questions discussed in this category

Would you recommend treating asymptomatic bacteriuria in a kidney transplant patient who has a ureteral stent in place?
1 Answer available
Do you recommend to continue acyclovir to prevent HSV infection in an HIV patient with CD4 count more than 200 and with high viral load?
1 Answer available
Do you recommend chronic oral suppressive antibiotics after initial intensive treatment of 6-8 weeks in patients with culture-negative prosthetic joint or bone infections with retained hardware?
1 Answer available
What factors do you consider when deciding between monotherapy with an antipseudomonal cephalosporin and combination therapy in ICU patients with Pseudomonas aeruginosa bloodstream infection who are not in septic shock?
Bavaro et al., PMID 40088112
1 Answer available
Do you treat complicated pneumonia with a drained empyema longer if Streptococcus anginosus is cultured, either in isolation or with other organisms, compared to cases in which it is not?
1 Answer available
What are your vaccine recommendations while patients are on biologics?
2 Answers available
How do you balance the risk of unnecessary treatment with acyclovir against the risk of delaying treatment in encephalitis cases where CSF pleocytosis is absent?
Habis et al., PMID 39096271
1 Answer available
Is there a specific criteria that you use to determine if a patient with respiratory symptoms should have a multiplex respiratory test performed?
1 Answer available
What is your approach to management of CIED in a patient with community-acquired Staph aureus bacteremia who clears blood cultures quickly with negative follow up blood cultures within 72 hours of antimicrobial therapy and negative TEE?
Would you still routinely ask for CIED removal, or would you pursue PET/CT for further evaluation and consider keeping CIED if PET/CT negative?
4 Answers available
What is your re-immunization strategy after auto SCT for patients with myeloma on dara/len maintenance?
Prior guidance was mostly derived in the era of len maintenance +/- adding a PI for high-risk patients. Do you avoid live vaccines?
2 Answers available
In drawing blood cultures from a central line to evaluate for CLABSI, do you advise drawing separate blood cultures from each port in case of dual or triple lumen line?
If yes, what is the rationale for doing that? 
3 Answers available
What is your approach to duration of fidaxomicin in a patient receiving treatment for first C difficile infection while also receiving concurrent antibiotics for an infection? 
Do you extend the course of fidaxomicin past initial 10 days to at least 3-7 days after completion of antibiotics?
1 Answer available
Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?
2 Answers available
How long do you treat uncomplicated gram-negative rod bacteremia in solid organ transplant recipients?
1 Answer available
Would you consider antifungal prophylaxis for immunocompromised patients with COVID-19 requiring mechanical ventilation, considering the high risk of invasive pulmonary aspergillosis in patients with severe COVID-19?
Feys et al., PMID 37691392 
1 Answer available
Do you recommend the use of ampicillin/ceftriaxone for prosthetic valve endocarditis due to ampicillin-susceptible Enterococcus faecium?
5 Answers available
When do you recommend limited or targeted respiratory pathogen testing versus a full respiratory pathogen panel in a patient presenting with URI symptoms?
In other words, are there benefits to identifying URI pathogens that do not necessarily have targeted therapies (e.g., rhinovirus, non-COVID-19 Corona...
1 Answer available
What is your approach to antiviral treatment of HSV acute retinal necrosis?
Is there a role for oral antiviral therapy alone (as opposed to induction with IV) and for what duration? And is there a role for ongoing suppressive ...
1 Answer available
Do you routinely recommend D-mannose or probiotics for patients with recurrent urinary tract infections?
Advani et al., PMID 40095957
5 Answers available
Do you prefer Vancomycin or Daptomycin for gram positive coverage in culture negative prosthetic valve endocarditis considering both Corynebacterium and Enterococcus are notable possible pathogens?
1 Answer available
What do you think about chronic suppressive therapy for HSV-2 in a patient with positive antibodies but no prior clinical outbreak?
Would you expect the presence of antibodies to indicate either immunity from contracting the infection, or otherwise risk of transmitting a latent inf...
1 Answer available
In light of recent measles outbreaks, have you adjusted your vaccination counseling or preventive strategies for adult immunocompromised patients?
1 Answer available
What is your preferred agent for fungal prophylaxis in a patient post lung transplant with abnormal LFTs?
Do you consider isavuconazole to be less hepatotoxic than other azoles?
2 Answers available
Is there any role for prophylactic bronchial artery embolization in immunocompromised patients with invasive pulmonary aspergillosis?
1 Answer available
Do you treat Stenotrophomonas maltophilia bacteremia with combination therapy and if so, what is your preferred combination of antibacterials?
2 Answers available
Do you recommend routine neurosyphilis testing in patients being evaluated for dementia?
1 Answer available
How do you approach recommending ocular exams for asymptomatic candidemic patients considering the discordance between the IDSA and American Academy of Ophthalmology guidelines?
3 Answers available
How would you approach the management of posterior uveitis caused by Toxoplasma gondii in immunocompromised patients, considering the potential for atypical presentations and treatment resistance?
Miriam et al., PMID 39571607
1 Answer available
What is the interpretation of two IGRAs with negative mitogen wells, in the absence of immunosuppression?
A patient on meloxicam for LBP developed high, persistent fevers and no other symptoms. An IGRA, among many tests, was sent. The IGRA’s mitogen ...
3 Answers available
Do you routinely order karius in evaluation of culture negative prosthetic valve endocarditis?
3 Answers available
How do you counsel patients and doctors on antibiotic avoidance in myasthenia gravis?
In light of the publication from Uysal et al., PMID 40166923
2 Answers available
How would you approach treatment of latent TB for patients who cannot tolerate rifamycins or isoniazid due to allergy, intolerance, or drug-drug interactions?
4 Answers available
What is your preferred laboratory test to assess treatment response or infection resolution in patients with bacterial pneumonia?
For example, do you find trending WBC, procalcitonin, CRP, etc., more or less helpful?
1 Answer available
Are there instances when you use letermovir without the addition of acyclovir when managing a kidney transplant recipient for CMV prophylaxis?
3 Answers available
Do you manage antibacterials for enterococcal bacteremia differently in patients with severe immunosuppression?
2 Answers available
How do you approach a patient on anti-TNF with positive Quantiferon (previously negative) with negative chest x-ray and no symptoms?
11 Answers available
What steps do you take to ensure that partners of patients diagnosed with chlamydia receive treatment?
Do you take steps beyond recommending to the patient that their partner gets treated? Do you commonly provide an antibiotic prescription for the partn...
3 Answers available
Do you treat prosthetic joint infections after a two-stage revision arthroplasty with oral antibiotics for the full duration of therapy, assuming a susceptible oral option is available?
2 Answers available
How do you approach PJP prophylaxis in patients with rheumatic disease on corticosteroids?
Does the presence of ILD change your approach?
4 Answers available
Is there a role for dual antibiotic treatment with ethambutol and macrolide only, as opposed to three-drug antibiotic therapy, in the treatment of treatment-naive pulmonary MAC without cavitary disease?
4 Answers available
Do you recommend treating Candida albicans on urine culture from an indwelling catheter in a patient with septic shock?
3 Answers available
What workup is sufficient to determine if an aortic aneurysm is "mycotic/infectious" or not, in that you would not prescribe empiric antibiotic therapy?
1 Answer available
Do you recommend boric acid for patients with recurrent candida vulvovaginitis?
1 Answer available
How long do you treat Staphylococcus aureus pyomyositis with antibiotics?
2 Answers available
Do you routinely recommend treatment for patients with chronic osteomyelitis of long bones based on radiographic findings alone in the absence of superficial infection or recommend bone biopsy to evaluate for therapy?
1 Answer available
How have the results of the BALANCE trial, which demonstrated the noninferiority of 7 days of antibiotics compared to 14 days for non-S. aureus bloodstream infections, influenced your practice?
Daneman, et al., PMID 39565030
1 Answer available
Would you recommend imaging of the brain and lungs to investigate potential disseminated disease in a recent heart transplant patient with a skin nodule that grew Rhizopus?
1 Answer available
For which pediatric oncology patients do you start bacterial prophylaxis, inpatient or outpatient, and what is your antibiotic of choice?
1 Answer available
Which biomarkers or diagnostic tools do you prioritize to support the decision to start antifungal treatment in septic patients with no clear source of infection but at high risk for fungal infections?
4 Answers available
Do you regularly recommend an immunological workup for patients with suspected immunodeficiency or defer to immunology?
1 Answer available
What is the recommended fungal workup in an immunocompromised patient after 5 days of persistent fever?
Do you involve additional specialists, such as ENT, to further evaluate? Is there a particular algorithm followed by your institution, or it is just d...
3 Answers available
Do you routinely recommend adjunctive rifampin therapy for the management of Staphylococcus aureus native vertebral osteomyelitis?
1 Answer available
What is your approach to secondary prophylaxis for C difficile infection during concomitant antibiotic use in a patient with a history of C difficile infection?
1 Answer available
How do you integrate next-generation sequencing with traditional culture methods to improve the identification of fungal pathogens, especially in cases where routine cultures are negative when evaluating suspected prosthetic joint infections?
2 Answers available
What is your approach to therapy in patients with progressive Scedosporium pulmonary infection who are not candidates for surgical debridement?
1 Answer available
For which patients or under which circumstances do you recommend a 9-month over a 6-month course of isoniazid for treatment of LTBI?
1 Answer available
Do you transition to oral antibiotics to treat uncomplicated Staphylococcus aureus bacteremia after patients have improved with intravenous antibiotic therapy?
4 Answers available
Do you routinely continue dual antibiotic coverage or de-escalate to monotherapy based on peritoneal fluid culture sensitivities in patients with relapsing pseudomonas aeruginosa peritoneal dialysis peritonitis after peritoneal catheter removal?
1 Answer available
In light of recent measles outbreaks in the US, would you recommend an MMR booster for an immunocompetent patients born before 1957?
4 Answers available
Would you ever consider oral doxycycline for treatment of either gram-negative or gram-positive uncomplicated bacteremia?
2 Answers available
What factors should be prioritized when deciding the timing of CIED extraction in patients with high surgical risk or multiple comorbidities?
1 Answer available
Is arbovirus testing available in your state outside the traditional summer season?
1 Answer available
Are there situations where you would consider treating E faecalis or E faecium that grows from a respiratory culture?
1 Answer available
How would you manage persistent Norovirus diarrheal infections in a kidney transplant patient that are not responding to a decrease in the patient’s maintenance immunosuppressive regimen?
3 Answers available
Do you routinely recommend transition to dual PO antibiotic coverage for strep species and MRSA, for patients with purulent cellulitis and in the absence of culture data?
2 Answers available
Do you recommend to exchange nephrostomy tubes when a patient is diagnosed with a urinary tract infection in the absence of any overt signs of infection at the exit site?
In particular, in individuals who are know to have their urinary tract colonized with an organism, and they will periodically develop a urinary tract ...
2 Answers available
What is your preferred method for latent tuberculosis screening prior to outpatient hemodialysis initiation for a patient with new dialysis requirements?
3 Answers available
What duration of antibiotic therapy do you use for a loculated parapneumonic effusion that does not meet criteria for empyema?
6 Answers available
Do you prescribe linezolid to patients who are concomitantly on an SSRI?
8 Answers available
Do you routinely treat patients with neurosyphilis with IM penicillin for 1-3 weeks after completing a full treatment course of IV penicillin?
CDC Sexually Transmitted Infections Treatment Guidelines, 2021
2 Answers available
How long do you recommend that a patient wear a mask when resuming biologic infusions following a recent upper respiratory infection?
3 Answers available
Does your institution have formal policies or work flows to reduce unnecessary IGRAs ordered for patients on biologics?
2 Answers available
Do you use standard dose or "meningitis dosing" of antibiotics when treating epidural abscesses, in the absence of CNS symptoms?
7 Answers available
What agent and for how long would you treat a patient with asymptomatic azole-resistant C auris candiduria who is planning to undergo a urological procedure?
4 Answers available
How does trimethoprim-sulfamethoxazole's efficacy against S. pyogenes influence your empirical treatment of skin infections in regions with high resistance rates?
McCreary et al., PMID 37310038
2 Answers available
How would you manage and determine the duration of antibiotics for a patient with suspected chronic postoperative spinal implant infection, status post lumbar fusion, now presenting with loosened hardware on imaging, normal inflammatory markers, and no systemic infection symptoms?
2 Answers available
What is the preferred antibiotic treatment regimen for vancomycin-resistant Enterococcus faecium endocarditis assuming susceptibility to both daptomycin and linezolid?
1 Answer available
What factors should guide the choice between fosfomycin and nitrofurantoin for uncomplicated cystitis, given the reduced efficacy of fosfomycin?
McCreary et al., PMID 37310038
2 Answers available
Do you routinely recommend doxycycline for pregnant individuals with rickettsial diseases despite the historical concern for side effects in pregnancy?
McCreary et al., PMID 37310038
1 Answer available
In addition to ampicillin, is there any benefit to the addition of either gentamicin or Bactrim when treating a patient with listeria meningitis?
3 Answers available
What additional workup would you recommend for a patient with a liver abscess caused by Fusobacterium and Aggregatibacter, who has had unrevealing endoscopies and no other abdominal masses on a CT scan?
1 Answer available
For which patients could you consider direct oral amoxicillin challenge as opposed to skin testing for penicillin allergy de-labeling?
2 Answers available
Do you treat non-albicans strains of Candida on sputum culture or BAL in patients who are immunosuppressed?
2 Answers available
Do you usually recommend a modified diet for Clostridioides difficile infection (CDI)?
Either low fiber or high fiber, or other? Or probiotics?
1 Answer available
Do you routinely recommend diagnostic endoscopy for patients with persistent enterococcus bacteremia despite receiving adequate antimicrobial therapy and no clear nidus?
Rogers & Rice, PMID 38018162
2 Answers available
Does your hospital or institution have an Antimicrobial Stewardship Program (ASP), which oversees ID physicians, and if so, does the ASP have the authority to refuse an antibiotic prescribed by an ID consultant?
ASPs are common place. The studies supporting ASPs oversaw doctors, not specifically trained in Infectious Diseases. However, several institutions hav...
3 Answers available
For patients with candida species osteomyelitis who have undergone extensive surgical debridement, do you routinely still recommend 6-12 months of antifungal therapy or opt for a shorter duration?
1 Answer available
Is there any role for administering another course of recombinant zoster vaccine (Shingrix) in a previously vaccinated patient with RA, who is in clinical remission on JAK inhibitor but has had a breakthrough shingles infection?
The last SHINGRIX was about 4 years ago and both doses were given.
2 Answers available
What antibiotics would you use for empiric treatment of a brain abscess in patients allergic to penicillin, metronidazole, and vancomycin?
1 Answer available
Would you still consider adding clindamycin for streptococcal toxic shock syndrome in situations where the isolate is considered to be resistant?
1 Answer available
Do you routinely use two empiric antibiotics to cover for Pseudomonas aeruginosa in the management of CF exacerbations?
3 Answers available
Do you give chronic antibiotic prophylaxis for recurrent UTIs, including Pseudomonas aeruginosa, in a patient with retained ureteral stents?
4 Answers available
What is your approach to treatment of patients with fulminant C difficile infection who required ileostomy creation or colectomy?
Is there a role for oral vancomycin in these patients, or is oral vancomycin redundant if other routes of administration are being used (i.e intracolo...
1 Answer available
How do people approach non-HIV patients with hepatitis B, a negative Hepatitis B E antigen, normal LFTs and relatively low HBV DNA between 2000-20000?
2 Answers available
What is the interpretation of an IGRA with positive TB wells and negative nil and negative mitogen wells?
A patient on meloxicam for LBP developed high, persistent fevers and no other symptoms. An IGRA, among many tests, was sent. The IGRA’s mitogen ...
2 Answers available
For patients with spinal hardware infections, in what circumstances do you recommend 12 weeks over 6 weeks of antimicrobial therapy?
1 Answer available
What is your preferred dosing of IV ganciclovir for CMV disease in immunocompromised patients?
1 Answer available
What additional treatment strategies would you recommend for a patient with a Mycobacterium chelonae and Mycobacterium abscessus infection following bilateral prophylactic mastectomies and implant insertion, who has undergone multiple surgeries and an extended course of IV antibiotics selected based on sensitivities?
2 Answers available
How do you use CD4% in clinical practice in management of patients living with HIV?
7 Answers available
Would you consider using long-acting injectable cabotegravir/rilpivirine for pregnant women with HIV?
2 Answers available
Have you incorporated the use of linezolid in lieu of vancomycin plus clindamycin for empiric treatment of necrotizing fasciitis?
1 Answer available
Do you routinely recommend suppressive antibiotic therapy for patients with spinal hardware infections who have undergone surgical debridement with retention of hardware?
1 Answer available
What is your approach to anal pap screening among MSM with HIV, and if routinely recommend, starting at what age (assuming access to HRA)?
2 Answers available
Do you add gentamicin when treating prosthetic valve endocarditis secondary to viridans group Streptococcus with a penicillin-intermediate isolate (MIC >0.125 - <0.5)?
3 Answers available
Do you treat subarachnoid neurocysticercosis with albendazole alone, or with the addition of praziquantel?
1 Answer available
Would you start treatment for MAC in a patient with nodular bronchiectatic disease who has demonstrated radiographic progression but remains asymptomatic and smear-negative?
2 Answers available
How do you manage resistant infections that persist after stopping antibiotic therapy in patients with non-CF bronchiectasis?
1 Answer available
How do you approach management for patient's with HIV on ART with persistent low level viremia but no new resistance mutations identified?
1 Answer available
Is there any utility to trending Histoplasma serology titers to guide duration of therapy or treatment response for pulmonary histoplasmosis with negative urine antigen?
2 Answers available
Do you recommend, based on current evidence, avoiding antimotility agents in patients with non-fulminant C. difficile infection who have no evidence of ileus?
2 Answers available
Do you recommend procalcitonin to help convince other providers to stop antibiotics in patients with pneumonia in whom a non-infectious diagnosis is strongly suspected?
2 Answers available
What is your preferred oral regime with duration for treatment of onychomycosis?
How frequently can you repeat the oral course? 
4 Answers available
What patient-specific factors would influence your decision to initiate semaglutide therapy in patients with HIV-associated lipohypertrophy?
1 Answer available
Is it ever safe to use a biologic DMARD in a patient with RA who is on suppressive antibiotics due to a history of septic prosthetic arthritis?
2 Answers available
How would you approach treatment in a patient with refractory Coccidioidal meningitis who has previously been treated with IV amphotericin B?
1 Answer available
What is your approach to the use of Paxlovid for patients with risk factors for severe Covid-19 infection but who have received SARS-CoV-2 vaccines in light of the EPIC-SR trial findings?
EPIC-SR Trial
3 Answers available
Are there instances when you do not recommend tunneled dialysis catheter exchange in patients on hemodialysis who are found to have bacteremia?
4 Answers available
What duration of therapy do you recommend for patients with a vascular graft infection in which the graft has been removed and another graft placed in the infected space?
1 Answer available
What further evaluation do you pursue for patients who present with vague symptoms such as subjective fevers or intermittent night sweats, who have no pulmonary symptoms but have a positive IGRA?
1 Answer available
Do you ever favor cefazolin over ceftriaxone for bacteremia with susceptible E. coli?
1 Answer available
When do you discontinue contact precautions in patients known to be colonized with ESBL-producing Enterobacterales?
3 Answers available
For how long would you treat a patient with dematiaceous fungi growing on a native heart valve discovered at the time of valve replacement?
1 Answer available
How would you treat an asymptomatic patient with a positive Blastomyces antibody, evidence of prior granulomatous lung disease on imaging, and who may require immunosuppression in the future?
1 Answer available
Is there a role for beta-lactams as step-down oral therapy for uncomplicated gram-negative bacteremia?
If so, what antibiotic regimens do you use?
6 Answers available
What specific criteria or patient conditions would make you hesitant to use fluoroquinolones early in the treatment course for managing MSSA joint infections with oral antibiotics?
For example, baseline QT prolongation, elderly age group, or underlying heart disease?
3 Answers available
What is your preferred agent and duration to treat an epidural abscess due to azole-resistant candida species?
1 Answer available
Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?
1 Answer available
What is your preferred third antimicrobial agent for a patient with treatment-naive pulmonary MAC without cavitary disease and strict contraindications to utilization of rifampin or rifabutin?
3 Answers available
What approaches can we take to initiate therapy and improve survival rates in patients with HLH?
2 Answers available
Do you add adjunctive gentamicin and/or rifampin for treatment of prosthetic valve Staphylococcus aureus endocarditis?
3 Answers available
How do you factor cerebrospinal fluid (CSF) antibody results when deciding on the diagnosis and treatment of racemose neurocysticercosis, given the uncertainties associated with CSF antibody testing?
1 Answer available
What is your approach when cryptococcus serum or CSF antigen titers do not change despite treatment in HIV-positive patients with cryptococcal meningitis or invasive disease, but there is clinical improvement and cultures remain negative?
1 Answer available
How would you manage a patient with Crohn's disease on a biologic and presents with non-bloody diarrhea, normal-appearing mucosa on sigmoidoscopy but severe colitis on biopsy with a positive CMV stain?
Would you send a CMV DNA PCR in blood, and if you elect to treat with anti-CMV medication, how long would you treat and what parameters would you use,...
1 Answer available
What oral treatment options would you offer a patient with severe onychomycosis who is also on methotrexate for another condition?
2 Answers available
How would you manage a patient with progressive/refractory molluscum contagiosum who is well controlled on methotrexate for seropositive rheumatoid arthritis?
Are you aware of any data regarding relative risk of molluscum contagiosum infection in reference to DMARDs/biologics?
1 Answer available
What are the current treatment options for progressive multifocal leukoencephalopathy in patients without HIV/AIDS?
Are there any clinical trials underway to study additional therapies?
1 Answer available
What duration of antibiotics do you use in patients with Actinomyces osteomyelitis, i.e., do you stop after 6 weeks or do you give a longer oral antibiotic course?
1 Answer available
How do you decide between ceftolozane/tazobactam and ceftazidime/avibactam for empiric treatment of an infection due to difficult-to-treat Pseudomonas aeruginosa while awaiting additional susceptibilities?
2 Answers available
Do you favor timely bronchoscopy for diagnostics over close surveillance in mildly symptomatic patients with CT findings suspicious for NTM infection who are not able to expectorate?
4 Answers available
Do add a macrolide for immunomodulatory effect in patients with macrolide-resistant M. abscessus?
2 Answers available
Do you use steroids in the management of PJP pneumonia with severe hypoxia in HIV negative patients?
Data on the role of steroids in HIV negative patients with PJP has been conflicting.
2 Answers available
What is your approach to a positive PPD or IGRA in a patient with well-controlled HIV without significant TB risk factors?
3 Answers available
What are your top takeaways from ID Week 2024?
1 Answer available
Do you consider the use of tocilizumab in patients with COVID pneumonia who have had an improvement in supplemental O2 requirements but have significantly elevated inflammatory markers after day two of remdesivir and dexamethasone?
1 Answer available
What is the utility of granulocyte infusions in patients with neutropenia and severe infection?
1 Answer available
Do you avoid performing urine microscopy in patients with AKI who have COVID-19 given concern for potential aerosolization?
2 Answers available
Are there clinical scenarios in which you would start empiric treatment for pulmonary TB without microbiologic confirmation?
2 Answers available
When would you initiate exchange transfusion in babesiosis and significant hemolysis?
Is parasitemia >10% and severe hemolysis with Hb less than 7 enough to initiate this?
1 Answer available
Do you take into consideration a patient's serum albumin level in your decision to use ertapenem?
2 Answers available
Do you routinely recommend a lumbar puncture for patients with suspected ocular or otic syphilis in the absence of additional CNS symptoms?
3 Answers available
Do you routinely treat chronic sacral osteomyelitis when there is no plan for debridement or flap?
2 Answers available
What is your approach to recurrent asymptomatic bacteriuria in pregnancy for patients without personal history of recurrent UTIs or pyelonephritis?
Assuming patient already received an initial course of antibiotic treatment in response to a positive urine culture during routine screening early in ...
2 Answers available
How do you decide on the timing and number of blood cultures for suspected endocarditis given the differences in recommendations between the ESC guidelines and the Duke Criteria?
The ESC guidelines recommend obtaining at least three sets of blood cultures at 30-minute intervals before starting antibiotic therapy, each with 10 m...
3 Answers available
Would you treat a sputum culture positive for Aspergillus niger despite an atypical CT chest and a negative serum galactomannan in an immunosuppressed patient who is too high risk for bronchoscopy?
0 Answers available
How often do you see bony erosions in patients with Lyme arthritis?
1 Answer available
What is your approach to deciding when to stop therapy for cutaneous Mycobacterium chelonae infections?
1 Answer available
What infections should we rule out in patients who develop diarrhea on immunotherapy?
Chemotherapy is associated with acquiring C diff colitis. Does immunotherapy share that same risk and necessitate ruling out infection prior to anti-d...
1 Answer available
Do you routinely perform echocardiography in patients with Staphylococcus aureus bacteremia deemed low risk for metastatic infection, or do you selectively omit it based on specific clinical criteria?
Hendriks, et al., PMID 38576380
2 Answers available
Under what circumstances do you consider valacyclovir for the management of VZV disease of the CNS?
2 Answers available
When treating pancreatic body/tail lesions that result in significant dose spread to the spleen, what is your threshold to offer pneumococcal, hemophilus influenza, and meningococcal vaccines? 
2 Answers available
Are there any concerns with live vaccine innoculation and patients who are on denosumab?
1 Answer available
Is there a role for suppressive antibiotic therapy when it comes to chronic femoral/tibial osteomyelitis?
1 Answer available
In patients with possible Bartonella henselae infection and elevated IgG titer, what is the best way to confirm the diagnosis: tissue biopsy with Warthin-Starry staining, tissue sent for Bartonella henselae PCR, or tissue sent for culture?
1 Answer available
Do you routinely recommend IV systemic antibiotic therapy in additional to intravitreal antibiotic therapy for exogenous bacterial endophthalmitis?
1 Answer available
Do you preferentially avoid use of piperacillin-tazobactam for empiric anti-pseudomonal coverage in hospitalized patients due to risk of nephrotoxicity?
ACORN Randomized Clinical Trial 
1 Answer available
What steps do you recommend to ensure continued viral suppression and prevent drug resistance in an HIV patient on injectable cabotegravir and rilpivirine who misses their scheduled injection appointment by two weeks?
1 Answer available
How would you manage a patient with well-controlled HIV on Biktarvy, who is interested in switching to injectable HAART but also has a history of a prior Hepatitis B Infection?
2 Answers available
Do you routinely check cefepime levels in patient's with suspected cefepime-induced neurotoxicity?
1 Answer available
How would you approach treatment duration for patients with persistent candida species fungemia with a history of a prosthetic heart valve but negative TEE/CT PET and no other identifiable source of infection?
2 Answers available
Do you recommend starting anti-fungal prophylaxis for patients on systemic antibiotics who have a peritoneal dialysis catheter that is only currently being accessed for once weekly flushes?
1 Answer available
Would you transition from IV to oral antibiotics in a solid organ transplant recipient with uncomplicated gram-negative bacteremia?
Nussbaum et al., PMID 38195100
1 Answer available
Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?
1 Answer available
Is there a role for empiric scabies treatment in itchy patients without clear clinical signs of scabies? 
Do you empirically treat itchy patients -with a non specific rash- for scabies without obvious clinical findings for scabies? 
5 Answers available
Under which circumstances is there a role for reduction in immunosuppression post-SOT in a patient with recurrent CMV viremia and/or disease? 
1 Answer available
What is your approach to monitoring of inflammatory markers during treatment of native vertebral osteomyelitis?
3 Answers available
Do you give additional pneumococcal vaccines after a dose of PCV20 in patients with asplenia?
1 Answer available
Is there a role for routine LP in HIV patients with disseminated histoplasmosis even in the absence of CNS signs/symptoms?
Extrapolating from standard practice for management of cryptococcal antigenemia?
1 Answer available
Would you recommend starting a moderate-intensity statin in a patient under the age of 40 years old with HIV and a 10-year ASCVD risk estimate below 5%?
The REPRIEVE trial included participants who were between 40 and 75 years old.
1 Answer available
What is the preferred four-drug regimen for initial treatment of pan-susceptible tuberculous meningitis, given the need to achieve optimal CNS penetration?
1 Answer available
When would you add a third antibacterial agent in addition to macrolide and ethambutol for treatment of a patient with HIV and disseminated MAC?
1 Answer available
Is there a role for cefpodoxime for treatment of acute cystitis caused by an Enterobacterales isolate with resistance to cefazolin, but susceptibility to ceftriaxone?
Can cefpodoxime susceptibility be reliably extrapolated from ceftriaxone susceptibility? 
1 Answer available
In clinical practice, are you using single-dose liposomal amphotericin B for treatment of cryptococcal meningitis for patients living with HIV?
1 Answer available
Do you find HZV titers useful in diagnosing shingles sine herpete?
1 Answer available
Do you use combination antibiotic therapy for treatment of bacterial endocarditis due to gram-negative bacilli?
1 Answer available
How have you adjusted your practice for treatment of syphilis in light of the penicillin G benzathine shortage?
3 Answers available
What is your approach to monitoring blood parasite smears in an immunocompetent patient with babesiosis?
Do you continue smears until documented resolution, or by clinical progress?
1 Answer available
What is your approach to antimicrobial prophylaxis in adult patients undergoing treatment for HLH?
1 Answer available
Do you use combination therapy for persistent MSSA bacteremia?
If yes, which combination(s)?
1 Answer available
Under what circumstances would you recommend the maternal RSV vaccine for a pregnant patient if nirsevimab will also be available for the infant after birth?
1 Answer available
Is there a role for secondary CMV prophylaxis in solid organ transplant patients?
1 Answer available
Under what circumstances would you recommend early fecal microbiota transplantation over antibiotic treatment or bezlotoxumab in a patient with recurrent C. difficile infection?
1 Answer available
Have you used Karius to aid in the diagnosis of a non-resolving pneumonia, with negative bronchoscopy, biopsy, and other infectious work up in an immunocompetent patient?
1 Answer available
Do you routinely ask for removal of a indwelling central line (PICC or tunneled catheter) in a patient with pseudomonal bacteremia from known source with otherwise appropriate clinical improvement on anti-pseudomonal antibiotic therapy?
1 Answer available
How exhaustive (especially considering cost) should an immunological workup be for patients with extensive, recurrent, or deep seated Staph aureus infections without obvious immunocompromise (e.g. cancer, diabetes, steroids) or recurrent breaks in skin integrity?
1 Answer available
Do you recommend lifelong antibiotic prophylaxis, or do you prefer a more selective approach based on risk factors in asplenic patients without a history of severe infections?
2 Answers available
Is there any role for additional antiviral therapy during rebound from COVID-19 infection after a course of Paxlovid?
2 Answers available
Are there clinical circumstances in which there is a role for steroids in treatment of calcified neurocysticercosis associated with perilesional edema and seizures?
1 Answer available
Do you administer prophylactic antibiotics to prevent VAP following intubation in patients with acute brain injury?
Do the findings of the PROPHY-VAP trial influence your approach?
2 Answers available
How long would you treat an upper urinary tract infection in a patient with acute obstructive pyelonephritis due to a kidney stone status-post urinary stenting without yet removal of the stone?
4 Answers available
Do you recommend routine ophthalmologic exam for all patients with hypervirulent Klebsiella pneumoniae bacteremia?
1 Answer available
Do you choose an antibiotic with CSF penetration, such as nafcillin over cefazolin, in the setting of MSSA endocarditis with septic emboli to the brain (assuming no concomitant meningitis or brain abscess)?
3 Answers available
Do you consider use of convalescent plasma early in disease course in COVID-19 induced ARDS in mechanically ventilated patients?
Do the results of the recent study (Misset et al., PMID 37889107) showing reduction in 28-day mortality in patients with high neutralizing antibody ti...
1 Answer available
How do you approach a positive Quantiferon/PPD test result in a patient for whom testing is sent without a clinical indication and who does not have a risk factor for TB exposure nor TB reactivation?
Do you routinely offer latent TB treatment in these cases?  
2 Answers available
How do you approach restarting cDMARDS/bDMARDS in a patient with active RA after incidence of disseminated CNS VZV infection while on tofacitinib?
1 Answer available
Do you routinely refer all patients with cutaneous leishmaniasis with a species associated with mucocutaneous leishmaniasis to ENT for comprehensive nasal/oropharyngeal evaluation, or do you refer only if mucocutaneous involvement is suspected based on careful clinical assessment and/or bedside exam?
1 Answer available
Do you adhere to the standard 5-day minimum treatment duration for community-acquired pneumonia, or have you used shorter courses for certain low-risk patients?
1 Answer available
Have you used oral vancomycin as prophylaxis for C difficile infection in patients admitted for allogeneic hematopoietic cell transplant?
2 Answers available
Is there a risk of hepatitis C activation with rituximab in a patient who has a history of HCV treated with antivirals and who is in sustained viral response?
1 Answer available
How do you counsel HIV patients with an undetectable viral load on breastfeeding?
2 Answers available
What is your approach to use of D-mannose for prevention of recurrent uncomplicated cystitis?
Especially in light of the results of the randomized clinical trial published on 8/2024 in Jama Internal Medicine by Hayward et al., PMID 38587819.
1 Answer available
Do you periodically check a urine culture for patients without dysuria but who have a history of struvite kidney stones and urinary tract infections with urease producing organisms?
1 Answer available
Do you use oral fosfomycin as a treatment option for uncomplicated cystitis due to ESBL producing E coli?
1 Answer available
For how long would you treat Klebsiella aerogenes folliculitis of the face manifesting as a cystic lesion?
Would you combine antibiotics with isotretinoin?
2 Answers available
Do you recommend antibiotic prophylaxis for an ESKD patient with a tunneled dialysis catheter who is planned for a dental procedure?
2 Answers available
What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?
Would it be safe to resume and if so, when?
2 Answers available
Do you consider late latent syphilis adequately treated if a patient receives a 10-14 day course of IV ceftriaxone for another indication?
Or would you still offer penicillin G benzathine once weekly concurrently?
1 Answer available
Would you give treatment to a male patient with subjective dysuria but no objective pyuria with Ureaplasma urealyticum detected by PCR from urine?
1 Answer available
For how long do you recommend treatment for latent tuberculosis prior to initiation of anti-TNF therapy?
6 Answers available
How long would you treat a patient with recent history of TAVR presenting with E faecalis bacteremia with unclear source with TEE showing thickened valves but no obvious vegetation?
2 Answers available
How long do you treat an isolated bacterial liver abscess which has either undergone percutaneous drainage or for which an indwelling drain is placed?
3 Answers available
Is history of GBS a contraindication for all future flu vaccines?
2 Answers available
How do you apply the CDC PrEP guidelines for cisgender women, particularly when faced with underreported risk behaviors or uncertain partner HIV status?
1 Answer available
What is your approach to duration of systemic antibiotics for treatment of isolated bacterial endophthalmitis in the absence of bacteremia or other deep-seated metastatic foci of infection?
1 Answer available
What is your approach to a patient with undetectable MMR titers checked prior to or during immunosuppression and a history of MMR vaccination in childhood?
Is there a role for booster vaccination and if so, how do you approach the timing when a patient is already on a biologic for immunosuppression? 
1 Answer available
How long do you continue PJP prophylaxis in a patient with GPA who is able to wean steroids and remains only on rituximab for maintenance therapy?
1 Answer available
How do you treat a patient with a gram-negative infection with resistance to imipenem but sensitivity to meropenem and negative for Carbapenem resistant organism by xpert Carba-R-assay?
1 Answer available
Have you incorporated the use of steroids for patients with severe community-acquired pneumonia?
In light of published data from the CAPE COD trial...
1 Answer available
Is there a role for repeat surveillance blood cultures in patients with prosthetic valve endocarditis without associated cardiac abscess after a 6 week course of antibiotic treatment without surgical intervention?
1 Answer available
Is there a role for chronic suppressive oral or inhaled therapy for recurrent Burkholderia cepacia pneumonia causing frequent hospitalizations in a patient with severe bronchiectasis with or without underlying cystic fibrosis?
3 Answers available
How do you approach a patient who has anterior uveitis and is referred for evaluation of ocular TB with a positive Quantiferon gold (as part of their workup) in countries with low TB incidence?
2 Answers available
What is your approach to treatment of macrolide-sensitive localized bone/joint MAC disease?
1 Answer available
Does a low serofast RPR titer (such as 1:1 or 1:2) in the setting of a remote history of appropriately treated latent syphilis in a patient with now uveitis of yet unknown etiology referred from ophthalmology for possible ocular syphilis make a diagnosis of ocular syphilis less likely?
What is your approach to guiding ophthalmologists regarding our clinical suspicion for ocular syphilis and does the quantification of the titer help i...
1 Answer available
Are contact precautions effective at preventing MRSA transmission in healthcare settings?
2 Answers available
Have you applied the POET trial to clinical practice?
1 Answer available
What is current best practice with regards to antibacterial prophylaxis in patients with hematologic malignancy and resolved neutropenic fever (>72 hours)?
1 Answer available
How long do you continue antibiotics after cholecystostomy tube placement for acute cholecystitis?
Since the COVID-19 pandemic, increasingly we see management of acute cholecystitis with cholecystostomy tubes as opposed to surgery, even amongst pati...
1 Answer available
What isolation policies are Rheumatology offices employing for both staff and patients diagnosed with COVID-19 given the new CDC guidelines?
CDC Healthcare Guidance CDC Isolation and Work Restriction Guidance CDC Immunocompromised Guidance
1 Answer available
What antibiotic, antifungal and antiviral prophylaxis you give post CAR-T therapy, and what is the duration?
1 Answer available
In which patients do you prefer daily standard three-drug therapy for non-cavitary pulmonary MAC as opposed to three times a week dosing?
2 Answers available
Do you repeat a lumbar puncture in a patient living with HIV diagnosed with and treated for neurosyphilis and if so, when?
1 Answer available
What duration of therapy do you use for treatment of Legionella pneumonia in an immunocompetent host without associated empyema or extrapulmonary infection?
2 Answers available
In patients with HTLV-1 associated acute T-cell leukemia, is there any clear benefit of adding antivirals?
If yes, would you go with Zidovudine monotherapy versus combining with interferon-alpha? And what would be the preferred dose and duration? 
1 Answer available
Do you recommend testing for HPV in patients with oral lichen planus?
2 Answers available
Should checking a urinalysis with reflex to culture be part of the standard work up for fever in an ICU patient with a urinary catheter?
2 Answers available
Can non-16/18 HPV types cause ASCUS and squamous cervical metaplasia on biopsy within 3 months of acquisition, or would it take longer?
1 Answer available
What is the preferred treatment regimen for cardiovascular syphilis, specifically syphilitic ostial coronary artery disease?
1 Answer available
How do you approach biologic initiation in patients with inflammatory arthritis and repeatedly indeterminate Quantiferon?
5 Answers available
How do you approach ongoing screening for TB in patients with a history of treated latent TB, but who have ongoing use of DMARDs and/or biologics given Quantiferon testing and PPD can remain positive?
How do you approach ongoing screening for TB in patients with history of treated latent TB, but have ongoing use of DMARDs and/or biologics given quan...
1 Answer available
For patients on PrEP, is there a role for HIV RNA PCR screening in addition to 4th generation antigen/antibody testing?
1 Answer available
What is your approach to working up diarrhea in an immunocompromised patient?
1 Answer available
Do you typically adjust or hold immunosuppression in a well-controlled RA patient who is being treated for Mycobacterium avium-intracellulare (MAI)?
1 Answer available
What is your approach to starting antiretroviral therapy in a patient living with HIV who is diagnosed with cryptococcal meningitis?
1 Answer available
What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?
2 Answers available
Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?
2 Answers available
For AML patients, when do you stop antiinfective agents?
At the time of count recovery or do you continue it throughout induction and consolidation?
1 Answer available
Given recent data for use of doxycycline as post-exposure STD prophylaxis, how have you applied its use in clinical practice?
4 Answers available
For how long do you treat an early spinal hardware infection secondary to MSSA after operative washout and retention of hardware?
1 Answer available
Do you treat patients with HIV-AIDS and positive cryptococcal antigenemia but negative CSF cryptococcal antigen with standard meningitis treatment given the potential for the postzone effect?
1 Answer available
When should vaccines be given if not received prior to the start of high dose radiation (40-50 Gy) to the spleen?
1 Answer available
How do you manage a patient with severe RA or SLE that worsens after stopping immunosuppressants due to having chronic foot ulceration?
2 Answers available
Do you consider anti-viral prophylaxis in patients taking JAK inhibitors who have recurrent uncomplicated Zoster infection, but would prefer not changing therapy?
2 Answers available
What is your approach to vaccinations and titers for patients with myeloma, who are immunosuppressed and do not have appropriate antibody responses to vaccines?
E.g., for a patient with myeloma, s/p induction therapy, and high-dose chemotherapy, followed by autologous rescue with inappropriate antibody respons...
3 Answers available
What is your approach to determining the need for continued isolation in the dialysis unit for an ESKD patient who had a positive hepatitis B surface antigen one year ago but who now has a negative HbsAg in the absence of treatment?
1 Answer available
What is the recommended treatment regimen for Mycoplasma genitalium in a pregnant woman?
1 Answer available
Is there ever a role for the use of CMV immune globulin for treatment of CMV viremia and/or disease?
1 Answer available
How do you approach immunosuppression in patients with a positive Interferon Gamma Release Assay and prior intravesicular BCG treatment for bladder cancer?
Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?
1 Answer available
For how long do you treat uncomplicated CRE bacteremia in an immunocompetent patient?
1 Answer available
What is your approach to monitoring patients with the indeterminate form of Chagas disease?
1 Answer available
Do you have a preference between Quantiferon Gold and T-spot TB for screening in patients starting immunosuppressive agents?
1 Answer available
Would you consider stepping down from an echinocandin to azole therapy prior to the end of an initial six-week course for fluconazole-susceptible Candida albicans endocarditis in the absence of valve surgery?
1 Answer available
Do you use letermovir as CMV prophylaxis in solid organ transplant patients?
1 Answer available
In patients taking biologics who are planning joint replacement and are known MRSA carriers do you perform decolonization prior to surgery?
0 Answers available
Given recent data from the REPRIEVE trial, how will you adapt your practice with regards to prescribing statins to patients living with HIV?
1 Answer available
How do you approach a well controlled HIV patient with diffuse cutaneous kaposi sarcoma who failed to respond to radiation, paclitaxel and monthly liposomal doxorubicin?
1 Answer available
Does management of NMDA receptor encephalitis change in a patient with HIV/AIDS?
1 Answer available
Would you anticoagulate a patient with splenic infarctions in the setting of CMV viremia?
If so, for how long? 
1 Answer available
How would you approach immunomodulatory treatment for systemic lupus associated protein losing enteropathy (PLE) in a patient whose clinical course has been complicated by significant infection?
Additionally, is it correct to assume that IV therapies might be preferred vs oral treatment given alterations in GI absorption in PLE? 
1 Answer available
Are there any non-beta-lactam antibiotic options for treatment of neurosyphilis in non-pregnant adults?
1 Answer available
After a course of treatment for neurosyphilis, do you administer an additional IM dose of penicillin G one week after finishing the course of IV penicillin therapy?
1 Answer available
How long do you continue surveillance with imaging and sputum cultures in a patient with NTM with no indications for treatment?
3 Answers available
How would you approach the use of JAK inhibitors in a patient with stable RA who is now starting treatment for pulmonary MAC infection?
Patient previously failed abatacept and Rituximab.
1 Answer available
What is the risk of serious bacterial infection in a febrile solid tumor patient who has not yet started cancer-directed therapy and has normal cell counts with no central line?
1 Answer available
When would you consider percutaneous mechanical aspiration of vegetation in right-sided endocarditis?
1 Answer available
Does your approach to treating latent tuberculosis differ in a patient on anti-fibrotic therapy?
1 Answer available
Do you rule out TB in patients with AIDS and lobar pneumonia?
What’s your threshold to get the three AFBs and place the patient in airborne isolation?
1 Answer available
Do you routinely monitor imaging or pulmonary function in patients with pulmonary TB after the completion of therapy?
1 Answer available
What is the optimal timing for Zoster vaccine administration for a patient who recently recovered from herpes zoster infection and is now planning to start B-cell depletion therapy?
1 Answer available
How do you approach COVID-19 vaccination in those with a prior history of glomerular disease?
2 Answers available
How do you approach management of patients with active RA and recurrent non-severe C.diff?
(Patient with active RA despite hydroxychloroquine)
1 Answer available
How do you approach the workup for a patient with persistently elevated inflammatory markers (CRP and ESR) whose history and exam do not point to a clear cause?
4 Answers available
Do patients on eculizumab or ravulizumab require repeat vaccination against meningococcal infection after a certain interval?
1 Answer available
Are you using the microbial cell-free DNA “Karius” test to aid in the diagnosis of an atypical pulmonary infection such as PJP or NTM?
2 Answers available
Do you use steroids in patients with respiratory failure who are infected with both influenza and COVID-19?
How do you approach which risk to accept given that steroids have evidence for use in COVID-19 while is suggestion for harm in using steroids in influ...
1 Answer available
Do you routinely isolate and test for TB in a patient incidentally found to have a miliary pattern of nodules on chest CT?
2 Answers available
What is the antifungal prophylaxis regimen that you use in patients on peritoneal dialysis who are receiving antibiotics?
1 Answer available
What is your approach to BK hemorrhagic cystitis not responding to cidofovir?
1 Answer available
How do you approach treatment of RA with methotrexate in a patient with treated Hepatitis C and normal liver function?
1 Answer available
Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
3 Answers available
Do you treat Candida spp isolated from a bronchoalveolar lavage?
1 Answer available
What topical or oral treatments do you recommend for patients with recurrent MRSA infections?
Do you recommend any changes to their personal hygiene practices? or changes to their environment?
1 Answer available
Would you consider prophylactic antifungal treatment prior to immunosuppressive therapies in a patient with previously treated pulmonary coccidiomycosis and residual parenchymal changes?
1 Answer available
Do you ever stop tobramycin prophylaxis in a patient with chronic bronchiectasis previously colonized with pseudomonas?
2 Answers available
Do you recommend IVIg and/or cytoreduction for patients with IgM MGUS with reciprocal depression in IgG and recurrent infections?
Infection is not part of the criteria for starting treatment both in UpToDate and in NCCN guidelines. 
1 Answer available
Do you hold IV iron in the setting of active infection?
1 Answer available
Which medications have the lowest risk of tuberculosis reactivation in patients with uncertain tuberculosis history and active rheumatologic disease?
2 Answers available
What is your approach to the treatment of PML-IRIS in patients with HIV who have progressed to AIDS?
1 Answer available
How do you approach DMARD therapy in patients with rheumatoid arthritis and chronic hepatitis B?
Hepatitis screening labs revealing Hep B ag and core positivity with positive PCR
2 Answers available
How do you approach patients with onychomycosis that does not respond to terbinafine and prolonged courses of fluconazole?
Would you switch to itraconazole or perform fungal cultures? When would you consider repeating the course of treatment? 
2 Answers available
How do you approach the timing of COVID-19 vaccination for patients with multiple sclerosis on B-cell depleting therapies?
3 Answers available
Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
1 Answer available
Is there a role for regular hepatitis and TB screening in patients on chronic immunosuppressive therapy in the absence of new risk factors or exposures?
1 Answer available
What infectious prophylaxis do you use for patients with newly diagnosed multiple myeloma?
How do you decide how long to continue?
1 Answer available
How do you think about biologic use in patients with underlying HIV infection?
2 Answers available
Do you hold tocilizumab for patients who are diagnosed with Covid and are with mild to moderate symptoms or non-hospitalized?
1 Answer available
Is there a role for antibody testing to confirm vaccine response for patients on rituximab after COVID-19 vaccination?
1 Answer available
When would you consider checking JC virus prior to initiating biologic therapy?
1 Answer available
Do you routinely offer fungal prophylaxis for patients on BTK inhibitors?
Can experts comment on fungal pneumonia risk with individual BTK inhibitors as seen in ELEVATE-RR and whether this impacts their management decisions?
3 Answers available
How are you timing the third dose of the COVID-19 mRNA vaccine in patients on rituximab?
1 Answer available
How long would you treat with antimycobacterials before starting biologic DMARD in a patient with latent TB and active rheumatoid arthritis?
1 Answer available
In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?
2 Answers available
How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?
Is there a role for empiric antibiotics if there is history of opportunistic infection?
1 Answer available
How would you manage an active rheumatoid arthritis patient on suppressive antibiotic therapy for ocular HSV who has abnormal liver function tests?
1 Answer available
Do you treat HIV/AIDS-associated CNS vasculitis with antiretrovirals alone or in combination with steroids?
1 Answer available
How would you recommend dosing the MMR or other live vaccines for patients with rheumatoid arthritis on immunosuppressive medications such as anti-TNF alpha therapy?
For example, healthcare workers who require these vaccines for employment
1 Answer available
How do you treat RA in patients with pulmonary mycobacterium avium complex (MAC) infections?
1 Answer available
Are there particular concerns related to the use of B-cell depletion therapies such as rituximab for rheumatic disease during the COVID-19 pandemic?
1 Answer available
How would you manage methotrexate therapy in an active rheumatoid arthritis patient undergoing treatment for latent TB with rifampin?
Do you stop methotrexate or adjust the dose? 
1 Answer available
When are you recommending bone marrow transplant recipients receive the SARS-CoV-2 vaccine?
Does your recommendation differ between autologous and allogeneic transplants? Does your recommendation differ in allogeneic transplant recipients wh...
2 Answers available
How do you approach the evaluation of patients referred for chronic lyme disease and counsel patients regarding this entity?
1 Answer available
How does a history of splenectomy alter how you counsel patients on the infection risk of TNF inhibitors or other biologics?
1 Answer available
Are you recommending the mRNA COVID-19 vaccines to your patients with immune mediated inflammatory diseases?
5 Answers available
Which immunosuppressed patients with SLE would benefit from antibiotic prophylaxis to prevent pneumocystis pneumonia?
1 Answer available
Would you hold all immunosuppressive medications for the first month of LTBI treatment, or just biologics?
1 Answer available
How would you attempt to determine the etiology of intracranial hemorrhage in a patient with newly diagnosed lupus and an active viral infection?
1 Answer available
Do you avoid any specific biologic therapies in HIV positive patients?
1 Answer available
Should tuberculosis screening be performed before beginning methotrexate for treatment of rheumatoid arthritis?
1 Answer available
In what situations do you check for HIV status in your workup for inflammatory arthritis?
1 Answer available
What is your approach to dental prophylaxis for patients on biologics?
1 Answer available
How do you manage patients who are Hepatitis B core antibody positive/surface antigen negative and starting a biologic DMARD (other than rituximab)?
1 Answer available
During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?
Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?
1 Answer available


Papers discussed in this category

The New England journal of medicine, 2007-01-25
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
Arthritis Rheumatol, 2016 Jan
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis care & research, 2012-05
2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis.
Arthritis care & research, 2017-03
Rates of Serious Infections in HIV-Infected Patients Receiving Tumor Necrosis Factor Inhibitor Therapy for Concomitant Autoimmune Diseases.
Clin Exp Dermatol, 2018 May 24
Treatment of psoriasis with ustekinumab in a patient with HIV-related Kaposi sarcoma.
Blood, 2015-10-29
Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2008-10
Prophylactic antibiotic usage for Pneumocystis jirovecii pneumonia in patients with systemic lupus erythematosus on cyclophosphamide: a survey of US rheumatologists and the review of literature.
Clin Rheumatol, 2006 Dec 21
Infection-related morbidity and mortality in patients with connective tissue diseases: a systematic review.
Rheumatol Int, 2020 Sep 18
High rates of severe disease and death due to SARS-CoV-2 infection in rheumatic disease patients treated with rituximab: a descriptive study.
N Engl J Med,
Clinical practice. Care of the asplenic patient.
Mediterr J Rheumatol, 2020 Jun 11
Infections in Patients with Rheumatoid Arthritis in the Era of Targeted Synthetic Therapies.
Clin Infect Dis,
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011-03
Seroprotective titers against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipients.
Ann Rheum Dis, 2019 Aug 14
2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases.
Annals of the rheumatic diseases, 2022 Nov 03
2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases.
Frontiers in immunology, 2021 Apr 12
Using Routine Laboratory Markers and Immunological Indicators for Predicting Pneumonia in Immunocompromised Patients.
Seminars in hematology, 2013-07
Evaluation and management of patients with isolated neutropenia.
Neurology, 2020 Jul 29
Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study.
Cells, 2018 Dec 28
Ocrelizumab Depletes CD20⁺ T Cells in Multiple Sclerosis Patients.
Arthritis Rheum,
Tuberculosis associated with therapy against tumor necrosis factor alpha.
Ann Oncol, 2021 Mar 18
Association of Clinical Factors and Recent Anti-Cancer Therapy with COVID-19 Severity among Patients with Cancer: A Report from the COVID-19 and Cancer Consortium.
J Clin Oncol, 2021 Jul 26
Acalabrutinib Versus Ibrutinib in Previously Treated Chronic Lymphocytic Leukemia: Results of the First Randomized Phase III Trial.
Journal of neurovirology, 2018-06
Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.
Lancet Oncol, 2019 Oct 23
Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial.
Arthritis Care Res (Hoboken), 2021 Jul
2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Clin Liver Dis (Hoboken), 2018 Aug 22
Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance.
Scientific reports, 2017 Aug 10
Analysis of Factors Influencing Diagnostic Accuracy of T-SPOT.TB for Active Tuberculosis in Clinical Practice.
Clin Microbiol Infect, 2018 Feb 07
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).
Urology, 1982-09
Prevention of cyclophosphamide-induced hemorrhagic cystitis.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009-03
Intravesicular cidofovir for the management of BK virus-associated cystitis.
Clin Infect Dis, 2005 Jan 21
Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation.
Pediatr Transplant, 2014 Sep 08
Successful treatment of hemorrhagic cystitis after hematopoietic stem cell transplantation with intravesical hyaluronic acid.
J Clin Oncol, 2021 Apr 30
Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation.
Pediatr Infect Dis J, 2014 Nov
Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.
Bone Marrow Transplant, 2006 Mar
Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation.
Perit Dial Int, 2022 Mar
ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment.
Kidney Int Rep, 2021 Oct 06
COVID-19 Vaccination and Glomerulonephritis.
Kidney360, 2023 Mar 01
COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry.
Kidney Int, 2022 Sep 10
Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased.
Kidney360, 2021 Dec 03
COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.
Nephrol Dial Transplant, 2022 Jul 26
Perspective on COVID-19 vaccination in patients with immune-mediated kidney diseases: consensus statements from the ERA-IWG and EUVAS.
Clin Kidney J, 2021 Dec 21
Clinical spectrum of gross haematuria following SARS-CoV-2 vaccination with mRNA vaccines.
Clin Exp Nephrol, 2021 Nov 13
Gross hematuria after SARS-CoV-2 vaccination: questionnaire survey in Japan.
Kidney Int, 2021 Sep 14
COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?
J Am Soc Nephrol, 2022 Nov 04
A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination.
J Am Soc Nephrol, 2020 Jul 17
Kidney Biopsy Findings in Patients with COVID-19.
PET Clin, 2020 Feb 11
18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis.
Rheumatology (Oxford), 2022 Jul 22
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.
The Journal of thoracic and cardiovascular surgery, 2017-12
Contracts with people who inject drugs following valve surgery: Unrealistic and misguided expectations.
Tex Heart Inst J, 2022 Nov 1
Use of AngioVac Vacuum Aspiration for Refractory Endocarditis in a Postoperative Mustard Patient.
Circulation, 2020 Dec 17
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Catheter Cardiovasc Interv, 2022 Jul 26
Treatment of cardiac device-related infective endocarditis utilizing the new T20 curve catheter and flow saver with the Inari mechanical aspiration system.
Multimed Man Cardiothorac Surg, 2020 Sep 25
Percutaneous aspiration of vegetation from tricuspid valve infective endocarditis.
JACC Case Rep, 2022 May 04
Case Series of Percutaneous Mechanical Aspiration of Mitral Valve Endocarditis.
Circulation, 2015 Sep 15
Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.
Arthritis & rheumatology (Hoboken, N.J.), 2017-10
The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
Ann Am Thorac Soc, 2017 May
Minimizing Tuberculosis Risk in Patients Receiving Anti-TNF Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-01
Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
Human vaccines & immunotherapeutics, 2017 Feb
Recommended vaccinations for asplenic and hyposplenic adult patients.
Blood, 2020 Jun 18
Tocilizumab in patients with symptomatic Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-01-18
Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.
The New England journal of medicine, 2022 Mar 24
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
The Cochrane database of systematic reviews, 2018 Jul 24
Early versus delayed antiretroviral treatment in HIV-positive people with cryptococcal meningitis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 Jul 05
Early Antiretroviral Therapy Not Associated With Higher Cryptococcal Meningitis Mortality in People With Human Immunodeficiency Virus in High-Income Countries: An International Collaborative Cohort Study.
Chest, 2023 Feb 17
Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease.
The New England journal of medicine, 2014 Oct 01
Goal-directed resuscitation for patients with early septic shock.
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 2021 Jul 23
Sexually Transmitted Infections Treatment Guidelines, 2021.
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024 May 15
Effectiveness of Prophylactic Oral and/or Vaginal Probiotic Supplementation in the Prevention of Recurrent Urinary Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Trial.
The Journal of antimicrobial chemotherapy, 2014-05
Adverse events, healthcare interventions and healthcare utilization during home infusion therapy with daptomycin and vancomycin: a propensity score-matched cohort study.
Journal of clinical pharmacology, 2019 Oct 20
More Frequent Premature Antibiotic Discontinuations and Acute Kidney Injury in the Outpatient Setting With Vancomycin Compared to Daptomycin.
Journal of clinical microbiology, 2021 Mar 19
Evaluating the Rapid Emergence of Daptomycin Resistance in : a Multicenter Study.
Antimicrobial agents and chemotherapy, 2017 Jun 27
Development of High-Grade Daptomycin Resistance in a Patient Being Treated for Corynebacterium striatum Infection.
JAMA ophthalmology, 2019-06-01
Utility of Ophthalmologic Screening for Patients With Candida Bloodstream Infections: A Systematic Review.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016-02-15
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Ophthalmology, 2021 Jul 19
American Academy of Ophthalmology Recommendations on Screening for Endogenous Candida Endophthalmitis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023 May 24
Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011-08-01
Ocular manifestations of candidemia.
Antimicrobial agents and chemotherapy, 2012-06
Safety and tolerability of voriconazole in patients with baseline renal insufficiency and candidemia.

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