How would you approach grade 2 neurologic toxicity in a patient on daratumumab, dexamethasone, and lenalidomide for relapsed multiple myeloma?

Clarification of the question was made, and it was focused on peripheral neuropathy. The polyneuropathy in Dara/Rev/dex is mostly due to the Revlimid. Most neuropathy from rev, if any, is grade 1- 2. The first step will be to start with gabapentin without reducing the dose of Revlimid. It is a very good regimen, given 300 mg TID as starting dose (or a smaller dose of 100 mg or 200 mg) if the patient is older or frail or very sensitive to meds in general). Cymbalta or Lyrica are good second options. If no improvement, then dose reduction of Revlimid. I have rarely had to reduce Revlimid dosing due to peripheral neuropathy.