How would you approach potential SBRT to liver metastases in a patient on a VEGF inhibitor?
Would you alter your SBRT dose? How long would you hold the VEGF inhibitor before and after? Does the primary matter (e.g. NSCLC vs. colorectal)?
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How long do you request VEGF inhibitors be held before and after liver SBRT?
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1 Answer
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Radiation Oncology · Mayo Clinic, Rochester
Answered on
For patients who are on VEGF inhibitors, I would be very careful with dosing of radiation to nearby bowel and I discuss holding VEGF inhibitors for a time before, during and after radiation. There have been multiple reports of in field toxicity, particularly with respect to bowel (liver SBRT frequen...
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