There aren't any good established dose constraints in this reirradiation setting.  Pertinent open issues include the specific role of time in recovery of the bronchus and other central structures (e.g. what is the time threshold at which retreatment becomes more safe?) and the impact of combini...

Re-treatment of local recurrence after prior radiation in central tumors is very challenging, and poses substantial risk of treatment related toxicity. While typically the mechanism of death in NSCLC is distant disease, patients with isolated central recurrence are likely the group at highest risk o...