How would you approach the management of a patient with elevated iron saturation (60%) and ferritin (500s) with negative genetic testing for hemochromatosis?

I would approach this clinical scenario in the following manner:

Always starting with good medical and family history first.

• Is there any history compatible with secondary hemochromatosis (i.e., history of blood or multiple iron transfusions)?
• Could the patient be tested for other non-282Y genetic ...