How would you approach the treatment of an elderly patient with multiple myeloma and CALR+ myelofibrosis with elevated platelets?

Thank you! This is a great question and a very complicated case. Generally, I would be less concerned about thrombocytosis. I would focus more on the symptoms and splenomegaly that the patient may be experiencing. If they are not having significant MF-related symptoms or splenomegaly, then observati...