How would you approach treatment duration for patients with persistent Candida species fungemia with a history of a prosthetic heart valve but negative TEE/CT PET and no other identifiable source of infection?

Persistent fungemia in the presence of a prosthetic valve with no other identifiable source despite appropriate treatment is challenging. Few studies report high mortality in the nonalbicans candida group, and the risk increases if the patient is immunocompromised. A multidisciplinary management app...

Your question is all about the assessment, not the plan actually. The source is not evident, but it's present if there is persistent fungemia. Other work-ups should include ultrasounds of the limbs to look for septic thrombophlebitis (previous IV sites?) There could be a cryptic abscess that is elud...