How would you approach treatment of DLBCL in a patient on hemodialysis?

Topics: Hematologic Malignancies • Medical Oncology • Lymphoma • Hematology

How would you handle high risk features (eg double hit) with the limitations of dialysis?

Answer from: Medical Oncologist at Academic Institution

For R- CHOP based therapy it can be administered the day before dialysis with no dose adjustments. Only Cyclophosphamide has renal clearance and should be reduced by 50%. For more aggressive regimens it becomes more challenging as there is not enough data. This is what we would consider doing...

Comments

Medical Oncologist at NYU Winthrop Hospital
Thanks for your guidance in this difficult situati...

Answer from: Medical Oncologist at Community Practice

For elderly patient on HD R-mini CHOP day before HD is feasible.

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