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How would you decide on VRd vs DRd for initial management of transplant ineligible multiple myeloma?

Are there specific patient groups where you would choose one over the other? Are the cost differences significant enough to dissuade you from choosing one over another?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Nebraska Medical Center
Answered on

Both VRd and DRd are reasonable induction regimens for newly diagnosed transplant ineligible patients. DRd has the most direct evidence, as there is a phase III study (MAIA, Facon et al., NEJM, 2019) comparing DRd to Rd with both arms including treatment until progression in a transplant ineligible ...

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