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How would you interpret a negative ER by PCR via Oncotype, but positive (60%) based on IHC staining?

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Mednet Member

Medical Oncology · Huntsman Cancer Institute at the University of Utah

I would want pathology to be reviewed again to see if there are ER+ and ER- areas, to explain the discordance in ER expression via Oncotype Dx and IHC. It is possible that the Oncotype Dx was run on the ER- portion.

How would you interpret a negative ER by PCR via Oncotype, but positive (60%) based on IHC staining? | Mednet