How would you manage a frail patient with GCB DLBCL who is unable to complete R-CHOP but has moderate residual disease?

We need a little more information to answer this question. First, what was the stage at diagnosis? Why is the patient frail - is this disease related, or is this a result of therapy? The age of the patient can also assist in making this decision. Also, what is the moderate disease? Can this be inclu...

Pola + Rituxan.

If CR stops, monitor MRD. If no CR, proceed to CAR-T.