How would you manage a HR+/HER2+ breast cancer patient with no response during neoadjuvant TCHP?
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How would you manage a HR+/HER2+ breast cancer patient with no response after completion of 6 cycles of TCHP?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · Warren Alpert Medical School of Brown University
Answered on
A few thoughts:
- Although we know that patients with ER+/HER2+ are less likely to respond to neoadjuvant chemo and dual HER2-targeted therapy than those who are ER-/HER2+, I would confirm that the patient is truly HER2+; if the diagnosis was made by IHC, would send FISH or CISH.
- If the patient has ...
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