How would you manage a localized small cell carcinoma of the anal canal without nodal or distant disease?
Ki-67 > 95%, PET-CT negative for any additional disease.
Answer from: Medical Oncologist at Academic Institution
High-grade, poorly differentiated neuroendocrine carcinoma (NEC) of the anorectum is a highly aggressive malignancy associated with a very poor prognosis. For truly localized disease (FDG PET negative for extrapelvic and nodal disease), the outcomes are still poor. The majority of patients with...
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