How would you manage a male with a prior history of localized prostate cancer s/p radiation to prostate only (two years ago), who now presents with a T1N0 squamous cell carcinoma of the anus?

There is data where t1 no anal cancer was treated with RT alone with a localized field. There was low risk of recurrence of the outside treatment volume and that would be my approach to avoid overlap and given the chance of sphincter preservation.

Also, I have not used it but data also shows good ef...

Interesting case. I have treated 2 patients who have had PCs, and were, curatively, irradiated -> one with definite EBRT and ST-ADT, and the other with combined EBRT w/ brachy prostate boost with ST-ADT.

The anal cancers were both HPV negative.

I treated both with en face electron ports to the anus/...