How would you manage a patient with a solitary plasmacytoma with a partial response to RT?

Would you recommend surgical resection if feasible? Or just monitor every 3-6 months as NCCN guidelines suggest?

Would your management differ based on whether the lesion is osseous vs extraosseous?

Answer from: Medical Oncologist at Community Practice

A solitary osseous plasmacytoma can be higher or lower risk than an extra medullary plasmacytoma; for instance, a tonsillar plasmacytoma is different than one in lung parenchyma. The largest study I know about evaluating solitary plasmacytoma of the bone involved 206 patients without evidence ...

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Medical Oncologist at East Carolina University
Thanks for this response. The question was modifie...

Answer from: Medical Oncologist at Community Practice

If there was no elevation to begin with a serum light chain ratio or serum in the globulins, I would observe, but if there was an initial elevation of these with appearance of the plasmacytoma and partial reduction of those values along with partial shrinkage of the lesion, I would consider a surgic...

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