How would you manage a patient with isolated metastatic high grade sarcoma to inguinal and external nodes in a patient with BRCA+ mutation?

This patient had resection of the primary, requiring multiple resections to obtain an R0 resection, followed by adjuvant radiation to the primary. They did not experience local recurrence.

1 Answer

Mednet MemberInvited Expert

Medical Oncology · Emory University

Answered on

Ovarian cancer treatments can work for BRCA2+ leiomyosarcoma.

This has been published (Seligson et al., PMID 30541756) and I have had a couple of patients with BRCA2+ LMS. I had no luck with PARP inhibitors but one tremendous success with cisplatin, which produced a dramatic response in one heavily pretreated lady and got her another year+. In LMS, BRCA2+ is not from germline mutation but is somatic. I have a suspicion that the BRCA2+ subset of LMS accounts for occasional efficacy of DNA damaging...

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