How would you manage a patient with isolated metastatic high grade sarcoma to inguinal and external nodes in a patient with BRCA+ mutation?
This patient had resection of the primary, requiring multiple resections to obtain an R0 resection, followed by adjuvant radiation to the primary. They did not experience local recurrence.
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Emory University
Answered on
Ovarian cancer treatments can work for BRCA2+ leiomyosarcoma.
This has been published (Seligson et al., PMID 30541756) and I have had a couple of patients with BRCA2+ LMS. I had no luck with PARP inhibitors but one tremendous success with cisplatin, which produced a dramatic response in one heavily p...
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