How would you manage a patient with metastatic HCC on atezolizumab/bevacizumab who requires holding bevacizumab due to persistent proteinuria >2g?

How do you manage grade 2 or higher proteinuria in patients treated with atezolizumab/bevacizumab for HCC?

• Continue atezolizumab alone and monitor proteinuria
• Continue both atezolizumab and bevacizumab and add antihypertensive agents
• Hold both atezolizumab and bevacizumab until proteinuria resolves or improves and then restart atezo alone
• Hold both atezolizumab and bevacizumab until proteinuria resolves or improves and then restart both drugs
• Hold both atezolizumab and bevacizumab until consultation with nephrology
• Switch to alternative therapy with dual IO (eg STRIDE regimen durva/treme)
• Switch to alternative therapy with TKI alone
• Other