How would you manage a patient with osteoporosis on denosumab who develops significant renal insufficiency where it is difficult to continue denosumab due to increased risk of hypocalcemia (i.e. eGFR in the low 20’s)?
Answer from: at Academic Institution
This is an interesting question. Denosumab, unlike bisphosphonates, does not have a warning about use with renal insufficiency. However, denosumab does reduce osteoclast activity for a few weeks after the injection, and this can cause hypocalcemia in patients with renal insufficiency as these patien...
Comments
at Loma Linda University Thank you. This is helpful.
Can you share the reg...
at VA Greater Los Angeles Health Care System Excellent advice. I check calcium, magnesium, and ...
Thank you. This is helpful. Can you share the reg...
Excellent advice. I check calcium, magnesium, and ...