How would you manage a POLE mutated, p53 abnormal IA myoinvasive carcinosarcoma of the endometrium with no LVSI?
Do you offer observation for POLE mutated tumors?
Answer from: Radiation Oncologist at Academic Institution
No data I am aware of for POLE status portending for better prognosis in non-endometrioid histologies.
For this patient, I would treat as per our institutional (and NCCN-supported) standard, which is chemotherapy + cuff brachytherapy.
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Answer from: Radiation Oncologist at Community Practice
I would not change the management of IB and above non-endometrioid histology based on mutation analysis as almost all data is for endometrioid histology.