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How would you manage distal DVT in first trimester of pregnancy?

Cardiolipin was mildly positive and persistent after 12 weeks (29->28 MPL). No other significant provoking factors. The patient started on LMWH. What duration would you choose for anticoagulation? Are 3 months sufficient, or would you anticoagulate through the entire pregnancy? Would you consider this meeting the criteria for APLS?
1 Answer
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Hematology · Oregon Health & Science University
Answered on

This is an excellent question. Essentially, this is an individual with an acute, provoked distal DVT in the setting of pregnancy. ASH 2018 guidelines for management of VTE in pregnancy recommends antithrombotic therapy with LMWH for individuals with acute VTE (Bates et al., PMID 30482767). While the...

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