How would you manage JAK2+ polycythemia vera during pregnancy and postpartum?

There are not a lot of data to guide us given the relative rarity of PV in adults of child-bearing age but two published studies may be helpful.

An analysis of 129 pregnancies in patients with PV demonstrated that the combination of aspirin plus LMWH had a significantly lower risk of a spontaneous ab...

I agree completely with Dr. @Dr. First Last. We know that aspirin throughout pregnancy (How et al., PMID 33022566) helps outcomes. I use it in all patients regardless of traditional IPSET risk during pregnancy if they have ET. Consensus guidelines recommend 6 weeks of LMWH postpartum also. Phlebotom...

Asprin through the duration of pregnancy and to consider LMWH x 6 weeks post-partum during the period of highest risk