How would you manage sarcomatoid carcinoma of the prostate with poorly differentiated adenocarcinoma that is not amenable to surgery?

There is data on this rare histologic variant, albeit limited, and often in these situations we try to extrapolate from analogous areas with more data.

It is believed that the pathogenesis of these tumors, the epithelial and sarcomatoid components, arise from a single cell of origin, rather than sepa...

Sarcomatoid carcinoma of the prostate is too rare an entity to have specific guidelines regarding radiotherapy dosing or technique. This histology has been documented to occur in prostate cancer patients who received prior radiotherapy, which has led some authors to imply the radiation may be causat...