How would you treat a diffuse CNS myeloid sarcoma (aka chloroma/granulocytic sarcoma) without evidence of blood or bone marrow involvement?

Myeloid sarcoma prognosis is not good and treatment need high dose ARA-C based chemo As induction. Would consider IT chemo would consider Omaha as well. Patient will need after CR CS radiation inculded in the conditioning regimen to consolidate with Myeloablative transplant. HLA and donor activation...

Isolated myeloid sarcoma is a very rare condition effecting perhaps 1% of all pts with AML, so any therapeutic recommendations are merely educated guesses. Probably the best approach is some combination of systemic and local therapy (see MD Anderson report Leukemia 1&:1100, 2003) since many of these...

Careful pathology review is essential in confirming this entity given the unusual presentation (make sure this is not ALL). In addition, I would recommend FISH, cytogenetics, and a next gen sequencing for myeloid molecular panel for mutations that could be used to monitor disease progression or poss...