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How would you treat a patient with colon cancer that is dMMR/MSI-high with a solitary liver lesion that is deemed resectable?

Would you recommend pembrolizumab prior to surgery? Or after? Is there a role for FOLFOX?
1 Answer
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Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
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In patients with dMMR/MSI metastatic synchronous liver only resectable adenocarcinoma of the colon, synchronous or staged colectomy with liver resection or checkpoint inhibitor immunotherapy followed by synchronous or staged colectomy with liver resection are guideline recommended options. (NCCN Gui...

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