Mednet Logo
HomeQuestion

How would you treat a patient with emergence of EGFR C797S mutation at the time of progression on osimertinib given for EGFR T790M mutation?

1 Answers
Mednet Member
Mednet Member
Medical Oncology · Hematology Oncology Medical Group of Orange County

Although I don't have a personal experience, there are reports of adding 1st or 2nd gen EGFR TKI such as gefitinib or erlotinib to Osimertinib.

2017 Nov;12(11):1728-1732. doi: 10.1016/j.jtho.2017.08.006. Epub 2017 Aug 24.
Combination Osimertinib and Gefitinib in C797S and T790M EGFR-Mu...

Register or Sign In to see full answer