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How would you treat a patient with emergence of EGFR C797S mutation at the time of progression on osimertinib given for EGFR T790M mutation?
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Mednet Member
Medical Oncology · Hematology Oncology Medical Group of Orange County
Although I don't have a personal experience, there are reports of adding 1st or 2nd gen EGFR TKI such as gefitinib or erlotinib to Osimertinib.
J Thorac Oncol. 2017 Nov;12(11):1728-1732. doi: 10.1016/j.jtho.2017.08.006. Epub 2017 Aug 24.
Combination Osimertinib and Gefitinib in C797S and T790M EGFR-Mu...