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Head and Neck Cancers • Medical Oncology
How would you treat a patient with head and neck squamous cell carcinoma and adverse features with borderline renal function in the adjuvant setting?
Which of the systemic options would you give concurrently with radiation therapy in the adjuvant setting? According to NCCN guidelines, high dose cisplatin is preferred, but weekly cisplatin 40mg/m2, cetuximab, carboplatin + 5-FU, and carboplatin + paclitaxel are also options.
Answer from: Medical Oncologist at Academic Institution
In the postoperative setting, bolus-dose cisplatin (80-100 mg/m2) every 21 days with radiation is the preferred treatment for patients with positive margins or extranodal extension. If patients cannot tolerate high-dose cisplatin, weekly cisplatin can be considered. In one randomiz...
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