How would you treat a patient with head and neck squamous cell carcinoma and adverse features with borderline renal function in the adjuvant setting?

In the postoperative setting, bolus-dose cisplatin (80-100 mg/m2) every 21 days with radiation is the preferred treatment for patients with positive margins or extranodal extension. If patients cannot tolerate high-dose cisplatin, weekly cisplatin can be considered. In one randomized study of SCCHN ...